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Chinese factory supply 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy (4-hydroxy TEMPO) 2226-96-2 in stock with high standard We supply high quality 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy (CAS 2226-96-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy is orange crystals, while it's Molecular Formula is C9H18NO2. Tempol, a water-soluble piperidine nitroxide derivative having nonspecific radical-scavenging and superoxide dismutase (SOD) activity, protects cultured aerobic, but not hypoxic, cells against radiation-induced killing. Protection does not depend on intracellular thiols and does not involve O2-depletion. Tempol reacts with peroxyl radicals and can also oxidize DNA-bound metal ions, thereby interfering with OH? generation.
The CAS number of 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy is 2226-96-2.
More information of 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy 2226-96-2 are:
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Synonyms |
4-Hydroxy-2,2,6,6-tetramethylpiperidino-1-oxyl;Piperidinooxy,4-hydroxy-2,2,6,6-tetramethyl- (7CI,8CI);1-Oxyl-2,2,6,6-tetramethyl-4-piperidinol;2,2,6,6-Tetramethyl-4-hydroxy-1-piperidinyloxy radical;2,2,6,6-Tetramethyl-4-hydroxypiperidin-1-oxyl;2,2,6,6-Tetramethyl-4-hydroxypiperidine N-oxide;2,2,6,6-Tetramethyl-4-hydroxypiperidine-1-oxyl;2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy;2,2,6,6-Tetramethyl-4-hydroxypiperidinyl-1-oxyl;2,2,6,6-Tetramethyl-4-hydroxypiperidinyloxyl radical;2,2,6,6-Tetramethyl-4-oxypiperidine-1-oxyl;2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl;2,2,6,6-Tetramethylpiperidine-4-hydroxy-1-oxyl;4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinoxy;4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy;4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxy; |
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CAS Number |
2226-96-2 |
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Molecular Formula |
C9H18NO2 |
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Molecular Weight |
174.263 |
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Density |
1.187 g/cm3 |
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Melting Point |
69-71 °C(lit.) |
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Boiling Point |
269ºC |
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Flash Point |
146°(295°F) |
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HS CODE |
29333999 |
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PSA |
23.47000 |
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LogP |
1.28370 |
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Pka |
5.07[at 20 ℃] |
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.
InChI:InChI=1/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
Articles related to 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy:
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Article |
Source |
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Photoinduced oxidation of sterically hindered amines in acetonitrile solutions and titania suspensions (An EPR Study) |
Barbierikova, Zuzana,Mihalikova, Maria,Brezova, Vlasta , p. 1442 - 1454 (2012) |
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Reactions of nitroxides. Part XII [1]. - 2,2,6,6-tetramethyl-l-oxyl-4- piperidyl chloroformate - A new reactive nitroxyl radical. a one-pot synthesis of 2,2,6,6-tetramethyl-1-oxyl-4-piperidyl N,N-dialkyl-carbamates |
Zakrzewski, Jerzy,Krawczyk, Maria , p. 493 - 498 (2011) |
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