Organic Intermediates: Pharmaceutical Intermediates

Home - Products List - Organic Intermediates: Pharmaceutical Intermediates

Cyclen

  • Product Name: Cyclen
  • CAS: 294-90-6
  • Purity:
  • Appearance: off- white to slightly yellow crystalline powder

Contact Us: +86-15508631887(WhatsApp/WeChat)

Email:sales@finerchem.com

Inquiry

Factory Supply industrial standard Cyclen 294-90-6 In Stock

  • Molecular Formula:C8H20N4
  • Molecular Weight:172.274
  • Appearance/Colour:off- white to slightly yellow crystalline powder 
  • Vapor Pressure:0.00309mmHg at 25°C 
  • Melting Point:108-113 °C 
  • Refractive Index:1.5872 (estimate) 
  • Boiling Point:283.8 °C at 760 mmHg 
  • PKA:10.53±0.20(Predicted) 
  • Flash Point:129.5 °C 
  • PSA:48.12000 
  • Density:0.874 g/cm3 
  • LogP:-0.32640 

Cyclen(Cas 294-90-6) Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 2268, 1974 DOI: 10.1021/ja00814a056

Flammability and Explosibility

Notclassified

General Description

Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.

InChI:InChI=1/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2/p+4

294-90-6 Relevant articles

Preparation and animal biodistribution of 166Ho labeled DOTA for possible use in intravascular radiation therapy (IVRT)

Das, Tapas,Chakraborty, Sudipta,Banerjeel, Sharmila,Samuel, Grace,Sarma,Venkatesh, Meera,Pillai

, p. 197 - 209 (2003)

Owing to its favorable decay characteris...

A copper-cyclen coordination complex associated with a polyoxometalate anion: Synthesis, crystal structure and electrochemistry of [Cu(cyclen)(MeCN)] [W6O19]

Sarma, Monima,Chatterjee, Tanmay,Das, Samar K.

, p. 1114 - 1117 (2010)

The reaction between Cu(NO3)2?3H2O and a...

Isomerization kinetics of lanthanide(III) complexes with the pendant-arm macrocyclic ligand 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane

Pittet, Pierre-Andre,Frueh, Dominique,Tissieres, Veronique,Buenzli, Jean-Claude G.

, p. 895 - 900 (1997)

The 13C and 1H NMR spectra of the comple...

A new synthesis of cyclen (1,4,7,10-tetraazacyclododecane)

Weisman, Gary R.,Reed, David P.

, p. 5186 - 5187 (1996)

-

-

Kossai,R. et al.

, p. 1059 - 1062 (1979)

-

A practical synthesis of 1,4,7,10-tetraazacyclododecane, a pivotal precursor for MRI contrast agents

Ferrari, Marinella,Giovenzana, Giovanni B.,Palmisano, Giovanni,Sisti, Massimo

, p. 15 - 21 (2000)

A practical preparation of the versatile...

A microcalorimetric determination of the enthalpies of formation in solution of nickel(II) complexes with tetraaza macrocyclic ligands of varying size

Fabbrizzi, Luigi,Micheloni, Mauro,Paoletti, Piero

, p. 535 - 538 (1980)

The enthalpies of formation of nickel co...

A new, facile synthesis of 1,4,7,10-tetraazacyclododecane: Cyclen

Athey, Phillip S.,Kiefer, Garry E.

, p. 4081 - 4085 (2002)

This report outlines a new and efficient...

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

-

Paragraph 0058-0059, (2021/03/19)

To provide a metal complex that has high...

Preparation method of cyclen and intermediate thereof

-

, (2021/07/08)

The invention discloses a preparation me...

Preparation method of cyclen

-

Paragraph 0061; 0062; 0063, (2020/02/14)

The invention provides a preparation met...

Preparation method of cycleanine

-

Paragraph 0031-0050, (2020/02/10)

The invention provides a preparation met...

294-90-6 Process route

C<sub>14</sub>H<sub>24</sub>N<sub>4</sub>

C14H24N4

cyclohexane-1,2-dione
765-87-7

cyclohexane-1,2-dione

1,4,7,10-tetraazacyclododecan
294-90-6

1,4,7,10-tetraazacyclododecan

Conditions
Conditions Yield
With hydrogenchloride; In water; at 60 ℃; for 6h;
1,4,7,10-tetraazacyclododecane tetrahydrochloride
10045-25-7

1,4,7,10-tetraazacyclododecane tetrahydrochloride

1,4,7,10-tetraazacyclododecan
294-90-6

1,4,7,10-tetraazacyclododecan

Conditions
Conditions Yield
With hydrogenchloride;
95%
With potassium hydroxide; In water; at 0 - 10 ℃;
91.3%
With potassium hydroxide;
With sodium hydroxide; In toluene; at 40 ℃; for 1h; Reflux;
13.77 g
With sodium hydroxide; In water; toluene;
12 g

294-90-6 Upstream products

  • 10045-25-7
    10045-25-7

    1,4,7,10-tetraazacyclododecane tetrahydrochloride

  • 137145-78-9
    137145-78-9

    7-<2-(1,3-Dioxolan-2-yl)ethyl>-1,4,7,10-tetraazacyclododecane-1-carbaldehyde

  • 52667-88-6
    52667-88-6

    cyclen tetratosylate

  • 368864-09-9
    368864-09-9

    cis-octahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene-3,4-dione

294-90-6 Downstream products

  • 112193-83-6
    112193-83-6

    1-benzyl-1,4,7,10-tetraazacyclododecane

  • 67705-42-4
    67705-42-4

    1,4,7,10-tetrazatricyclo[5.5.1.0]tridecane

  • 114873-37-9
    114873-37-9

    1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

  • 138884-09-0
    138884-09-0

    1,4,7-tribenzyl 1,4,7,10-tetraazacyclododecane 1,4,7-tricarboxylate

Leave Your Message

Relevant Products